Fig. 1: Index of DHSs in the human genome.
From: Index and biological spectrum of human DNase I hypersensitive sites
a, DNA accessibility assayed across multiple biosamples (indicated) from the main human organ systems. Of 733 biosamples, 531 were derived from primary cells and tissues. b, Example locus on chromosome 1, showing DNase I cleavage density in haematopoietic biosamples (right) with cell type-selective differences. c, Outline of DHS index procedure; 76.5 million DHSs aggregated across individual datasets jointly delineate and annotate 3.59 million consensus DHSs. d, Examples of consensus DHSs with varying cell-type selectivity and genome positional stability. Annotations include consensus DHS coordinates (start/end), single-base ‘centroid’, ‘core’ region aggregating centroids across biosamples, and a unique numerical identifier. e, Number of organ systems across which DHSs are shared.
