Extended Data Fig. 7: Top labelled genes for selected components.
From: Index and biological spectrum of human DNase I hypersensitive sites
a–d, Top-scoring protein-coding genes per DHS component reflect their functional roles, as shown for lymphoid (a), myeloid / erythroid (b), stromal (c) and tissue-invariant (d) components. e–h, Top-scoring transcription factor (TF) genes per DHS component reflect their functional roles, as shown for placental (e), cardiac (f), digestive (g) and organ developmental/renal (h) components. Full gene regulatory landscapes used for labelling are shown, with GENCODE gene annotations, meta-DNase overlay track, and DHSs. i, Examples of component-annotated genes with discordant expression patterns. Coloured squares next to gene names indicate relevant components, in this particular case discordant with cell and tissue types with maximal expression.
