Extended Data Fig. 8: Annotation of genes with unknown function and pathways.

a–c, Two-dimensional projection coordinates generated using t-SNE on all genes significantly associated with a DHS component and shown selectively for subsets of gene categories, namely transcription factors (TFs; diamonds: ZNF TF genes) (a), lincRNA genes (b) and pseudo-genes (c). Indicated are the number of labelled genes in each combination of gene category and DHS component. Examples of labelled genes are shown as follows. a, Regulatory landscape of ZNF331; a poorly annotated zinc-finger (ZNF) TF gene (lymphoid and placental components). b, Regulatory landscape of BANCR; a long intergenic non-coding RNA (lincRNA) gene, recently associated with cardiomyocyte migration. c, Regulatory landscape of the pseudo-gene IGHGP (lymphoid component). d, DHS component labelling of MSigDB canonical pathways, through the regulatory landscapes of constituent genes. Shown are pathways with a significant association (5% FDR) and an observed/expected ratio of at least 2. The most strongly associated components are indicated for each pathway, with their source databases. e, Examples of three component-associated pathways from the KEGG database, with genes coloured according to their majority component.