Extended Data Fig. 10: Extendability of the DHS annotation framework.
From: Index and biological spectrum of human DNase I hypersensitive sites
a, Two-dimensional UMAP projection of 733 biosamples by way of their index DHS utilization, coloured by their strongest representative NMF component. Stars indicate the embeddings of 38 previously unseen immune-related DNase-seq peak call datasets. b, Area under precision recall curve (AUPRC) values for predicting per-biosample DHSs from DNase-seq signal alone, shown for a trophoblast biosample. c, AUPRC values for the matching trophoblast versus all other 732 biosamples. d, Top 20 biosamples matching the aforementioned trophoblast biosample in terms of AUPRC values. e, Top 20 biosamples (out of 733) matching an unseen CD4+ biosample in terms of AUPRC values.
