Fig. 2: A simple vocabulary captures complex patterning of DHSs.
From: Index and biological spectrum of human DNase I hypersensitive sites
a, DNA accessibility at 3.59 million consensus DHSs assayed across 733 biosamples encapsulated in a visually compressed DHS-by-biosample matrix. Recurring accessibility patterns indicate extensive sharing across cell contexts. Dark column (right) shows DHSs detected in (nearly) all datasets. b, Modular behaviour of DHS actuation illustrated by thousands of DHSs with similar cross-biosample accessibility patterns. c, Decomposition of DHS actuation patterns across 733 biosamples into 16 components using NMF. The cellular patterning of each DHS is described using a mixture of components, indicated by distinct colours. d, DHS component labels provide a regulatory vocabulary for DHSs. e, Component mixtures for ten example DHSs with varying degrees of component specificity. The biosample dataset most strongly associated with each component is shown. Bottom, annotation of individual DHSs with a single dominant component.
