Fig. 3: Regulatory annotation of human genes.
From: Index and biological spectrum of human DNase I hypersensitive sites
a, Over-representation of DHS components in gene bodies and immediate flanks (maximum 5 kb upstream and 1 kb downstream). b, Percentage of genes annotated with DHS components (GENCODE gene categories). c, Regulatory annotation of GATA1, FOXP3, HOXB9 and CDX2 genes. d, Two-dimensional t-distributed stochastic neighbour embedding (t-SNE) projection of DHS component enrichment patterns across genes, coloured by dominant significant component (number of genes per component indicated). e, f, Summarized view of number of genes per component. Top five results for all protein-coding genes (e) and TF genes subset (f), for selected components. g, Correspondence between regulatory annotation and RNA expression shown using relative transcriptional activity across a panel of component-matched tissues and cell types (log2 observed/expected ratios). h, Putative TF-dependent regulatory elements defined by DHSs exclusively sharing regulatory components with genes encoding a given TF that also contain an occupied (footprinted) cognate TF motif.
