Extended Data Fig. 6: Extracellular pore loops, FAM155A sequence alignment (partial), and auxiliary subunit comparisons. | Nature

Extended Data Fig. 6: Extracellular pore loops, FAM155A sequence alignment (partial), and auxiliary subunit comparisons.

From: Structure of the human sodium leak channel NALCN

Extended Data Fig. 6

a, Close-in view of the NALCN ECL loops from the DI, DIII and DIV PM, highlighting disulfide bonds (in stick representation), compared to the analogous ECLs from NaV1.7 (PDB: 6J8G), CaV1.1 (PDB: 6JPA), and CaV3.1 (PDB: 6KZP). b, Multi-sequence alignment of selected FAM155A-like proteins; for clarity, spanning only the parts of the cysteine-rich domain (CRD). N-terminal region (171-175) not shown. c, FAM155A-CRD and the MuSK Fzd-like CRD (PDB: 3HKL). d, Superposition of the NaV1.7-β1-β2 complex (PDB: 6J8G) onto NALCN. e, Superposition of the CaV1.1- α2δ-1-β1a-ɣ complex (PDB: 6JPA) onto NALCN.

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