Extended Data Fig. 11: Conservation analysis and potential protein interaction sites. | Nature

Extended Data Fig. 11: Conservation analysis and potential protein interaction sites.

From: Structure of the human sodium leak channel NALCN

Extended Data Fig. 11

a, Conservation analysis66 of NALCN highlighting the FAM155A docking site (FAM155A in grey surface rendering). Sequences used for analysis: Homo sapiens, Mus musculus, Rattus norvegicus, Xenopus tropicalis, Ictalurus punctatus, Danio rerio, Gallus gallus, Columba livia, Drosophila melanogaster, Aedes albopictus, Caenorhabditis elegans, Anisakis simplex. b, Superposition of NALCN, NaV1.7 (PDB: 6J8G), CaV1.1 (PDB: 6JPA), CaV3.1 (PDB: 6KZP) and HCN1 (PDB: 5U6P) based on the S5 segment, with only the S5 and S4-S5 linkers shown for clarity. c, Conservation analysis (as in panel a) shown for the NALCN CTD-region.

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