Extended Data Fig. 4: Comparison of NALCN with NaV and CaV channel structures. | Nature

Extended Data Fig. 4: Comparison of NALCN with NaV and CaV channel structures.

From: Structure of the human sodium leak channel NALCN

Extended Data Fig. 4

a, Helical S4-S5 linkers are highlighted by colour in NALCN, NaV1.7 (PDB: 6J8G), CaV1.1 (PDB: 6JPA), and CaV3.1 (PDB: 6KZP); intracellular view (left) and side views (right) are shown. b, Side view of NALCN, CaV1.1, NavPaS (PDB: 6A90) and NaV1.7 highlighting the DIII-DIV linker, CTD, and the β1a-subunit (of CaV1.1).

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