Fig. 1: Isolation of SARS-CoV-2 mAbs from infected patients with severe disease.
From: Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
a, Plasma neutralization profile of 40 patients against SARS-CoV-2 pseudovirus (highlighted are five top neutralizers chosen for further study). b, All 252 transfection supernatants were screened for binding to the S trimer and RBD, as well as for neutralization against SARS-CoV-2 pseudovirus and live virus. For pseudovirus neutralization, the 50% inhibitory dilutions (IC50) of each supernatant are plotted. For live virus, semiquantitative representation of the inhibition at a dilution of 1:50, with neutralization levels ranging from (−) for none to (+++) for complete neutralization, is plotted. Potent antibodies later identified are marked by vertical lines and labelled at the bottom. The antibodies from each patient are coloured as in a.
