Fig. 3: Epitope mapping of select neutralizing and non-neutralizing mAbs.
From: Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
a, Competition results of non-RBD binders (left) and RBD binders (right) in blocking binding of ACE2 or biotinylated mAb to the S trimer. In addition, the ability of each mAb to bind NTD and RBDmut is shown. The numbers in each box show the area under each competition curve (AUC) as tested by ELISA. Plus and minus signs indicate binding and no binding, respectively, of the mAb to the protein. The letters A to H at the bottom denote clusters of antibody epitopes defined by the competition experiments. b, Venn diagram interpretation of results from a and Extended Data Fig. 6b.
