Fig. 4: Cryo-EM reconstructions of Fab–spike complexes and visualization of neutralizing epitopes on the spike surface.
From: Potent neutralizing antibodies against multiple epitopes on SARS-CoV-2 spike
a, Cryo-EM reconstruction of 2-4 Fab in complex with the S trimer at 3.2 Å overall resolution. Density is coloured with RBD in green, NTD in orange, and other regions in grey. b, Cryo-EM reconstruction of 4-8 Fab in complex with the S trimer (ribbon diagram, coloured as in a) at 3.9 Å overall resolution, with RBDs in the ‘all-down’ configuration. c, Cryo-EM reconstruction of the 2-43 Fab in complex with the S trimer at 5.8 Å resolution reveals a quaternary epitope involving RBD from one subunit and another RBD from the next. d, Mapping of the Venn diagrams from Fig. 3b onto the surface of the viral spike.
