Extended Data Fig. 8: Structural comparison between C9orf72–SMCR8 and FNIP2–FLCN.
From: Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD
Left, structural alignment of full-length FNIP2–FLCN and C9orf72–SMCR8. Right, comparison between the longin dimers (top), DENN dimers (middle) and SMCR8 DENN with C9orf72 DENN domain (bottom).
