Extended Data Fig. 9: Chromosome clustering can be artificially induced through increased adhesion between chromosomes.
From: Chromosome clustering by Ki-67 excludes cytoplasm during nuclear assembly
a, Design of an inducible H2B–H2B interaction system. b, Live HeLa cells expressing H2B–mCherry–FKBP and H2B–mNeonGreen–FRB or only H2B–mCherry–FKBP were imaged before and after rapamycin addition. Z-projection; scale bar, 10 μm. c, Normalized chromosome convex hull area quantification as in b of 23 cells coexpressing H2B–mCherry–FKBP and H2B–mNeonGreen–FRB, versus 12 negative control cells expressing H2B–mCherry–FKBP alone. Lines and shaded areas indicate mean ± s.d.
