Extended Data Fig. 5: Correlation between L505 labelled protein and γ-secretase activity.
From: The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease
a, Structures of JC8, L505, L646, GY4 and L631. b, Western blotting analysis of 11Bt-labelled proteins in the absence or presence of its parent compound, a substrate binding site inhibitor pep11 and imidazole GSM, E2012. Labelled proteins were captured and analysed by western blotting for PS1-NTF (n = 1). c, Pearson’s correlation between γ-secretase activity (Aβ40, Aβ42 cleavage rates in Fig. 4d) and L505-labelled PS1-NTF (in Fig. 5c) in LOAD samples (n = 10). Linear regression analysis was used to calculate R and P values.
