Extended Data Fig. 3: Distribution of reticulocytes and RNA concentrations across Dantu genotypes.
From: Red blood cell tension protects against severe malaria in the Dantu blood group
Reticulocyte counts, and concentrations of RNA extracted from reticulocytes, were compared across Dantu genotypes. Reticulocyte count data were tested for 8 non-Dantu individuals, 7 Dantu heterozygotes and 7 Dantu homozygotes, while RNA concentrations were measured in 9 non-Dantu, 7 Dantu heterozygotes and 7 Dantu homozygotes. Medians are indicated by the middle red lines in the boxplots, with the 25th and 75th percentiles indicated by the tops and bottoms of each plot, and the total data ranges indicated by whiskers. Statistical comparisons across the three genotype groups were performed by a one-way ANOVA; pairwise comparisons between genotype groups were performed using Tukey’s HSD test, correcting for multiple pairwise comparison tests using Benjamini–Hochberg FDR. Significant differences were observed in reticulocyte count (non-Dantu versus Dantu homozygote, P = 0.0023) and RNA concentrations (non-Dantu versus Dantu homozygote, P = 0.0015; non-Dantu versus Dantu heterozygote, P = 0.0088). *P < 0.05; **P < 0.01.
