Extended Data Fig. 5: Representative membrane fluctuation spectra for non-Dantu, Dantu-heterozygous and Dantu-homozygous RBCs.
From: Red blood cell tension protects against severe malaria in the Dantu blood group
Example of contour detection and flickering spectra across genotype groups. a, Contour of an RBC (dashed blue line), showing the inner and outer bounds used in image analysis (green lines). b, Final contour of an RBC following image analysis of the frame in a. c, Mean square fluctuation amplitudes, <|h(qx)|2>, as function of modes qx for non-Dantu (green line), Dantu-heterozygote (orange line), and Dantu-homozygote (purple line) RBCs. Fitted modes 8–20. Dashed lines qx−1 and qx−3, respectively, indicate the two possible limiting behaviours when tension or bending modulus dominates. The error bars (not shown for clarity) were calculated as \(\mathrm{s.d.}/\sqrt{(n\times {\rm{d}}t)\,}\), where s.d. is the standard deviation, n the total number of frames, and dt the time gap between frames.
