Extended Data Fig. 1: CRISPR screens identify peroxisome components as contributors to ferroptosis sensitivity.
From: Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
a, STRING Protein Network analysis of the top OVCAR-8 screening hits. b, STRING Protein Network analysis of the top 786-O screening hits. c, Schematic diagram showing simplified illustration of the principle and work flow for the GeLiNEA method. d, Table showing the top pathways enriched in the 786-O screen hits using GeLiNEA. Overlap is the number of genes in common between a gene set and the screening hit list, nConnections is the number of connections between a gene set and the screening hit list, P values are computed using Supplementary Equation (1) and q values are P values adjusted for multiple testing using the Benjamini–Hochberg correction method. e, Table showing the top pathways enriched in OVCAR-8 screen hits using GeLiNEA. f, Venn diagram showing the overlapped CRISPR screen hits in OVCAR-8 and 786-O cells. g, Volcano plots showing the top hits in OVCAR-8 and 786-O genome-wide CRISPR screens. For presentation purposes, only genes that are enriched in the RSL3- or ML210-treated condition by ≥ 1.5 fold (log2FC ≥ 0.585) are plotted. See Methods for data analysis methods.
