Extended Data Fig. 4: Correlation analysis of GATA3 expression in human morula cells.
From: Initiation of a conserved trophectoderm program in human, cow and mouse embryos
a–d, Scatter plots showing positive correlation of GATA3 expression profile with GRHL2, CLDN4, RAB20 (a), PTGES, TFEB, PLAC8 (b), ATP6V1B1, FXYD4, SLC7A2 (c), and VGLL4 (d) expression profiles in human morula cells. n = 197 cells. r, Pearson correlation coefficient. Values are displayed as log-transformed size-factor-normalized counts. The black line corresponds to a linear regression model fitted to the data with 95% confidence bands. e, Scatter plots of selected genes implicated in embryonic stem cell pluripotency and/or enriched in precursors of the epiblast and ICM in human morula cells that were identified as negatively correlated with GATA3 expression. n = 197 cells. r, Pearson correlation coefficient. Values are displayed as log-transformed size-factor-normalized counts. The black line corresponds to a linear regression model fitted to the data with 95% confidence bands. f, Box plots of selected genes showing positive or negative correlation with GATA3 expression in human morula cells. n = 197 cells. Data are shown as TPM + 1. Boxes correspond to the first and third quartiles, horizontal lines to the median, whiskers extend to 1.5× the interquartile range and dots are outliers. More details about statistics and reproducibility are provided in Methods.
