Extended Data Fig. 4: Single base pair mutations and E3N conservation.
From: Dense and pleiotropic regulatory information in a developmental enhancer
a–s, Example embryos carrying individual E3N::lacZ variants with single mutations. Constructs are ordered from smallest to largest effect sizes. t, u, PhyloP scores across the E3N enhancer sequence. Locations of the single mutations and their PhyloP scores are highlighted as magenta bars. v, E3N sequence alignment between 10 Drosophila species. Scale bars, 100 μm (a). Embryos are matched to scale respectively (a – s).
