Extended Data Fig. 1: The bladder urothelium expresses multiple mechanosensitive proteins, and PIEZO2 is not required for sensory neuron pinch responses.
From: PIEZO2 in sensory neurons and urothelial cells coordinates urination
a, FISH in bladder tissue with probes against Krt20 (green) and Piezo1 (white). DAPI in blue. b, FISH in bladder tissue with probes against Krt20 (green) and Tmem63b (white). DAPI in blue. c, Z-projection of the standard deviation of responses from genital pinch in WT and d, Piezo2cKO DRG. e, Quantification of peak responses during pinch shown as percent of baseline (each data point is one cell). n = 3 DRGs, 40 cells for WT, 4 DRGs and 69 cells for Piezo2cKO DRGs.
