Extended Data Fig. 7: Clonal architecture analysis using single-cell DNA+Protein sequencing of select AML samples.
From: Single-cell mutation analysis of clonal evolution in myeloid malignancies
Samples shown have significant differences in community representation between the dominant clone and subclones further discussed in Extended Data Fig. 8. MSK71 (depicted with ***) is highlighted in Fig. 4c–f. Clonotype plot depicts the number of cells identified with a given genotype and ranked by decreasing frequency (top panel). Mean cell counts for each clone are depicted with 95% confidence intervals derived from random resampling analysis. Heat map (middle panel) shows the genotype of each identified protein coding mutation in the given clone with zygosity (wildtype = light pink, heterozygous = orange, homozygous = red). Heat map of the relative protein expression for each cell-surface protein (n = 7) in each identified clone (purple = high expression; green = low expression).
