Extended Data Fig. 9: Lung cell expression patterns of respiratory virus receptors.
From: A molecular cell atlas of the human lung from single-cell RNA sequencing
a, Dot plot showing expression in human lung cell types of entry receptors (indicated at left) for respiratory viruses (indicated at right, numbers indicate viral families) (SS2 dataset). Red shading, cell types inhaled viruses could directly access (epithelial cells and macrophages); darker red shading shows expression values for measles receptor NECTIN4 and rhinovirus C receptor CDHR3. b, Violin plots (left) and dot plots (immediately above violin plots) showing expression of coronavirus receptors ACE2, DPP4, and ANPEP in lung cell types (10x dataset, cell numbers given in Supplementary Table 2). Grey shading, cell types inhaled viruses can directly access. Doughnut plots (right) showing relative number of receptor-expressing cells of cell types viruses can directly access (shaded grey in a), normalized by their abundance values from Supplementary Table 1 (and refined by the relative abundance values in Fig. 1 and Extended Data Figs. 3 and 4). Note prevalence of AT2 alveolar cells for ACE2, receptor for SARS-CoV and SARS-CoV-2, and for DPP4, receptor for MERS-CoV, in contrast to prevalence of macrophages for ANPEP, receptor for common cold causing coronavirus 229E. For more details on statistics and reproducibility, see Methods.
