Fig. 2: New genome editors in development.
Major classes of genome editors include nucleases, base editors (BE), prime editors, PNAs, RNA editors and epigenome editors. The development of new editors involves mining metagenomic datasets and building upon existing editors, in part by tuning them for increased precision and accuracy. DNMT, DNA methyltransferase; Acr, anti-CRISPR protein; RT, reverse transcriptase; DN1S: dominant-negative mutant of tumour suppressor p53-binding protein 1, 53BP1; TALE-fusions, transcription activator-like effector-fusion with nucleases or cytidine deaminases (DddA).
