Extended Data Fig. 9: SETDB1 regulates METTL3–YTHDC1 recruitment.

a–d, Heat maps (a), UCSC snapshot (b), box plot (c) and aggregation plots (d) showing METTL3 enrichment levels on IAPEz-int in parental and Setdb1 CKO cells. P = 1.3 × 10⁻⁴⁸, two-sided paired t-test. e–h, Heat maps (e), UCSC snapshot (f), box plot (g) and aggregation plots (h) showing YTHDC1 enrichment levels on IAPEz-int in parental and Setdb1 CKO cells. P = 5.0 × 10⁻¹⁰⁰, two-sided paired t-test. Uniquely mapped ChIP–seq reads were used in a–c, e–g. Uniquely + randomly mapped ChIP–seq reads were used in d, h. Heat maps were ranked according to METTL3 density in parental cells in descending order in a, e. For the box plots in c, g, the middle line and lower and upper hinges of the box plot correspond to the median and the first and third quartiles, respectively. The whiskers extend from the hinges to no further than 1.5 × IQR from the hinge. Outlying points are plotted individually.