Fig. 2: Hamster infections with ΔPRRA SARS-CoV-2.
From: Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
a, Schematic for primary challenge with SARS-CoV-2. b–e, Two groups of male hamsters (n = 4 in each group) were challenged with 105 PFU of wild-type (black) or ΔPRRA (blue) SARS-CoV-2, and evaluated for weight loss (b), disease score (c), viral titre from nasal wash (d) and viral RNA from oral swabs (e). f–i, Twenty-eight days after infection, hamsters infected with wild-type (black) or ΔPRRA (blue) SARS-CoV-2 were rechallenged with 105 PFU of wild-type SARS-CoV-2 and evaluated for weight loss (f), viral titre from nasal wash (g), viral RNA from oral swabs (h) and PRNT50 dilution using sera from hamsters after primary challenge and rechallenge (i). Data are mean ± s.e.m. P values from two-tailed Student’s t-test.
