Extended Data Fig. 1: Furin cleavage site in SARS-CoV-2 S.
From: Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
a, Diagram of the coronavirus S protein domains and cleavage sites. The sequences of the indicated group-2B coronaviruses were aligned according to the bounds of total S, S1, N-terminal domain (NTD), receptor-binding domain (RBD), C terminus of S1 (CTS1) and S2. We extracted sequence identities from the alignments, and constructed a heat map of sequence identity using EvolView (https://www.evolgenius.info/evolview/) with SARS-CoV-2 WA1 as the reference sequence. b, Alignment of the furin cleavage site of SARS-CoV-2 and the corresponding amino acids identities found in closely related group-2B coronaviruses. The PRRA insertion is unique to SARS-CoV-2. c, Representative plaque morphology of wild-type and ΔPRRA SARS-CoV-2.
