Extended Data Fig. 6: Variable contacts obscure the organization of the nerve ring.
From: A multi-scale brain map derived from whole-brain volumetric reconstructions
a, Cluster analysis of unperturbed membrane contact datasets M1, M2, M3 and M4. Clustering results for membrane contacts predicted to combine core and variable contacts (M3) and overwhelmingly variable contacts (M2, M1) significantly and increasingly diverge from five consensus clusters, indicated by large numbers of small clusters. b, Cluster analysis of (unperturbed) L4 and adult datasets. Both the unperturbed M4 and adult contact sets yield six clusters rather than the five clusters found in the perturbed population models (Fig. 1c, Extended Data Fig. 5). The additional cluster results from a split of the taxis cluster into two. This split of the taxis cluster is not observed in either the perturbed M4 or the perturbed adult contact sets, even with half of the noise levels observed empirically, indicating that the split is unlikely to be robust across a population of animals. For all cluster-frequency matrices, row and column ordering and colours are the same as the perturbed \(\tilde{{{\mathbb{M}}}^{4}}\) population dataset (Extended Data Fig. 5i). Matrix element (i, j) is 1 if cells i and j cluster together and 0 otherwise. Top: dendrogram of the hierarchical clustering.
