Extended Data Fig. 2: Crosslinking mass spectrometry analysis of the NLRP1–DPP9 complex.
From: DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation
a, Summary of BS3 crosslinking between DPP9 and NLRP1. High-confidence crosslinked peptides are displayed, and residue ranges are labelled and colour-coded by domain. Crosslinked lysine pairs are indicated in red text. Cα–Cα distances between lysine residues (in red) interpreted by the final NLRP1–DPP9 model are shown, along with the figure panels that show them in detail. All detected peptide pairs are tabulated in Source Data. b, Overview of BS3-mediated crosslinks. c–h, Close-up views highlighting crosslinked lysine pairs (red) interpreted by the final NLRP1-DPP9 model.
