Extended Data Fig. 4: Structural determination of the NLRP1–DPP9 complex with VbP.
From: DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation
a, Purification of the NLRP1–DPP9 complex in the presence of VbP by ion-exchange chromatography. The ternary complex peak is shaded in green and labelled with an arrow. b, A representative (of >1,000 images) cryo-EM micrograph. c, Representative 2D class averages. d, Workflow for the determination of the structure of the NLRP1–DPP9–VbP complex. e, Map–map and map–model FSC curves. f, Local-resolution distribution of the final map calculated with ResMap44.
