Extended Data Fig. 9: Structural analysis of MDB1 and various modes of RIFIN–receptor interaction.
From: Structural basis of malaria RIFIN binding by LILRB1-containing antibodies
a, Triangular architecture of LILRB1-containing MDB1 antibody Fab and structural comparison. Inside the ellipse is shown a schematic view of MDB1 with RIFIN attached to one arm of the Fab. The insets show structural superimposition of MDB1 domains on a non-inserted antibody and on apo LILRB1 (upper left: VH–VL region aligned with PDB 6P3B; upper right: CH–CL region aligned with PDB 6P3B; bottom right: LILRB1 insertion aligned with PDB 4LLA). b, Comparison of LILRB1/LAIR1 (grey) recognition by RIFIN PF3D7_1373400 (yellow) and RIFIN PF3D7_1040300 (PDB 7JZI, cyan). c, Comparison of LILRB1 (D1D2 in grey, D3D4 in red) recognition by RIFIN PF3D7_1254800 (PDB 6ZDX, green) and RIFIN PF3D7_1373400 (yellow).
