Extended Data Fig. 5: Multibody refinement and conformational dynamics analysis of the full-length structure.
From: Structure of human telomerase holoenzyme with bound telomeric DNA
a, Summary of the multibody refinement strategy and principal component analysis13. The best two subsets from global 3D classification were subjected to multibody refinement using two masks for the H/ACA lobe (yellow) and the catalytic core (cyan). b, Principal component analysis for 3D class 2. c, Principal component analysis for 3D class 5. The first and last frames of the eigenvector series of the first six principal components are shown. Curved arrows indicate the movements. d, Top 10 hTR ensembles modelled by DRRAFTER into the refined full-length 3D class 2 map (Supplementary Data 2). e, Top 10 hTR ensembles modelled by DRRAFTER into the refined full-length 3D class 5 map (Supplementary Data 3). hTR is shown in blue, and the protein subunits are in grey.
