Extended Data Fig. 4: Comparing the structure of the LigIV–XRCC4–XLF scaffold among the LR synaptic complex, the SR synaptic complex and previously published models.
From: Structural basis of long-range to short-range synaptic transition in NHEJ
a, Structure of XRCC4–XLF from the LR complex is shown in comparison to the XRCC4–XLF filamentous repeat crystal structures and the ones from the SR complex (both copies). The XLF dimer is used to align all of the models shown here. Solid lines are aligned with the coiled-coils of XLF (vertical) and XRCC4 (tilted), and the angles in between are shown. Dashed lines are aligned with the C-terminal half of the coiled-coil domain of XRCC4 when full helices are present, and the bending angles are also shown. b, XRCC4 in the crystal structure of the human and yeast LigIV–XRCC4 complexes24,34 are shown after aligning with XRCC4 in the LR complex shown in a. The bending of the coiled-coil domain of XRCC4 is more similar to the one in the SR than in the LR complex. c, Structure of the LigIV–XRCC4 complex from the LR complex is shown in comparison to human and yeast LigIV–XRCC4 crystal structures and ones from the SR complex (both copies). Colour codes for XLF, XRCC4 and LigIV BRCT domains are the same as in Fig. 1.
