Fig. 3: Cross-neutralization of first infection wave and 501Y.V2 virus across all participants.

Neutralization of the virus from the first wave (a) or 501Y.V2 (b). Sigmoidal fits were performed to the means of plasma neutralization results from the first wave (red points) and second wave (blue points) across all participants excluding a participant with plasma immunity elicited by SARS-CoV-2 with only the E484K substitution. Data are mean ± s.d. of n = 13 plasma donors infected with a first-wave virus and n = 6 plasma donors infected with a second-wave virus. c, Plasma PRNT₅₀ as a function of plasma source (columns) and infecting viral variant (rows). Blue rectangles highlight homologous (HM) neutralization for which virus and infection wave are matched; yellow rectangles highlight heterologous, cross-neutralization (HT) for which virus and plasma are from different infection waves.