Extended Data Fig. 7: Functional state of myeloid cells across disease cohorts.

a, Percentage of cells positive for each IMC channel, as classified by univariate Gaussian mixture models per disease group. b, Percentage of channel-positive cells for each metacluster. Values represent a column-wise Z-score. c, Absolute (top) and relative (bottom) frequency of SARS-CoV-2 S⁺ cells per disease group. d, Proportional abundance of SARS-CoV-2 S⁺, IL-6⁺ and pSTAT3⁺ cells across disease groups. e, Proportional amount of SARS-CoV-2 S⁺ cells grouped by metacluster and disease group. f, Proportional frequencies of cells positive for SARS-CoV-2 S⁺ cells by metacluster and disease group. g, h, Heat map of single macrophages or neutrophils (g) (columns) and functional markers (h) (rows) with cells grouped by SARS-CoV-2 S positivity. i, j, Intensity of IMC channels per single cell, depending on SARS-CoV-2 S positivity for macrophages (i) and neutrophils (j). k, Mean channel intensity for all metaclusters dependent on SARS-CoV-2 S positivity. In c, d, f, **P < 0.01; *P < 0.05, two-sided Mann–Whitney U-test, pairwise between groups, Benjamini–Hochberg FDR adjustment.