Extended Data Fig. 10: Survival data and functional studies evaluating MHCI ablation, CD8 depletion, and NK depletion in Setdb1 KO cells.
From: Epigenetic silencing by SETDB1 suppresses tumour intrinsic immunogenicity
a, Overall survival for ICB-treated WT mice inoculated with control and Setdb1 KO B16 (left) or LLC (right) cells with intact (B2m WT) or deficient (B2m KO) MHCI, as detailed in Fig. 4f and Methods. Statistics by log-rank test. b, Overall survival for ICB-treated WT mice inoculated with control or Setdb1 KO B16 (left) or LLC (right) cells that received intraperitoneal injections with isotype (left), CD8-depleting (middle), or NK-depleting (right) antibodies starting on day −3 before tumour challenge and continuing every 3 days until day 18, as detailed in Fig. 4f and Methods. Statistics by log-rank test. *P < 0.05; ***P < 0.001.
