Fig. 1: RBD–NP immunization induces robust antibody responses.
From: Adjuvanting a subunit COVID-19 vaccine to induce protective immunity
a, SARS-CoV-2 spike-specific IgG titres in sera following immunization with RBD–NP and the indicated adjuvant measured by ELISA. Boxes represent median, and 25th and 75th percentiles and whiskers show the range. b, c, Serum neutralizing-antibody titres determined by authentic SARS-CoV-2 assay at indicated time points. The black line represents the geometric mean of all data points and numbers show GMT on day 42 (b) and subsequent time points (c). IC50, half-maximal inhibitory concentration. d, Neutralizing-antibody titres against live wild-type (circles) or B.1.1.7 or B.1.351 variant (squares) SARS-CoV-2 virus measured in serum on day 42. Numbers indicate GMT. e, The fold change in neutralizing-antibody titres for the B.1.351 variant versus wild-type SARS-CoV-2. f, Serum neutralizing-antibody titres against the live wild-type (circles) or B.1.351 variant (squares) viruses measured on day 42 or day 154. a, b, e, Two-sided Mann–Whitney rank-sum test. c, f, Two-sided Wilcoxon matched-pairs signed-rank test. Each symbol represents one monkey. n = 4 (O/W), 10 (AS03) and 5 (all other groups).
