Extended Data Fig. 6: Immune correlates of protection.

a, b, Heat map showing two-sided Spearman’s correlation between peak nasal (a) and pharyngeal (b) viral load (day 2) and various immune parameters. All measurements were from peak time points (day 42 for antibodies, day 25 for plasmablast, and day 28 for T cell responses). The P values were corrected for multiple-testing. Asterisks represent statistical significance (*P < 0.05, **P < 0.01, ***P < 001 and ****P < 0.0001). c, Spearman’s correlation plots between peak nasal (left) or pharyngeal (right) viral load and the frequency of NP-specific IL-2⁺TNF⁺ CD4 T cells measured at day 28, 1 week after secondary immunization. d, Spearman’s correlation between the frequency of NP-specific IL-2⁺TNF⁺ CD4 T cells measured at day 28 and nAb response measured on day 42. The error bands in b and c represent 95% confidence limits. N = 4 for control and O/W, 5 for all other groups.