Extended Data Fig. 3: Cell-mediated immune responses to RBD–NP immunization.
From: Adjuvanting a subunit COVID-19 vaccine to induce protective immunity
a, RBD-specific CD4 T cell responses measured in blood at time points indicated on the x axis. The differences between time points within a group were analysed by two-sided Wilcoxon matched-pairs signed-rank test (*P = 0.016, **P < 0.01). b, Pie charts representing the proportions of RBD-specific CD4 T cells expressing one, two, or three cytokines as shown in the legend. c, NP-specific CD4 T cell responses in blood at time points indicated on the x axis. d, Ratio of frequencies of RBD-specific to NP-specific CD4 T cells expressing cytokines indicated within each plot. Boxes show median, 25th and 75th percentiles and the whiskers show the range. The dotted horizontal lines indicate a ratio of 1. N = 4 for O/W, 10 for AS03 and 5 for all other groups.
