Extended Data Fig. 5: Additional structural comparisons.
From: Structure of the human Mediator–RNA polymerase II pre-initiation complex
a, Comparison of the human Mediator–PIC structure (this study) with the free PIC structure25 reveals a different orientation of the Pol II RPB4–RPB7 stalk. The core PIC regions of the Mediator–PIC (in colour) and free PIC (in white) structures were superposed on the 10-subunit Pol II core. Mobile elements in the stalk are indicated and conformational changes between complexes are depicted by red arrows. b, Comparison of the yeast and human Mediator–PIC structures reveals a different relative orientation of the Mediator middle module. The human (in colour) and yeast9 (in white) Mediator–PIC structures were superposed on the well-conserved neck and fixed-jaw domains of the Mediator head module. Conformational changes of Mediator submodules are depicted by red arrows. The proximal tail region of human Mediator was omitted for clarity.
