Extended Data Fig. 1: Timeline of experimental design.
From: MARK4 controls ischaemic heart failure through microtubule detyrosination
a, Timeline of the experimental design for Fig. 1d, e. Investigation of the effect of total MARK4 deficiency on cardiac function using the model of LAD coronary artery ligation to induce myocardial infarction. Echocardiography (Echo) and histological analyses were performed at the indicated time points. b, Timeline of the experimental design for Fig. 2a–c. Investigation of the effect of total MARK4 deficiency on cardiac function at 24 h after myocardial infarction. Echocardiography, circulating cardiac troponin and histological analyses were performed at the indicated time point. c, Timeline of the experimental design for Fig. 2d and Extended Data Fig. 3a, b. Investigation of the effect of MARK4 expression in haematopoietic cells on cardiac function using the LAD ligation model. BM, bone marrow; BMT, bone marrow transplantation. Echocardiography analysis was performed at the indicated time points. d, Timeline of the experimental design for Fig. 2e and Extended Data Fig. 3c–e. Investigation of the effect of MARK4 expression in cardiomyocytes on cardiac function using the LAD ligation model. Tm, tamoxifen. Mark4 cKO, Mark4 conditional knockout mice. Echocardiography analysis was performed at the indicated time points.
