Extended Data Fig. 4: NMF-based correlation map of the cell and motif enrichment. | Nature

Extended Data Fig. 4: NMF-based correlation map of the cell and motif enrichment.

From: A proximity-dependent biotinylation map of a human cell

Extended Data Fig. 4

a, NMF-based map of the cell generated from preys with a Pearson correlation score across NMF ranks of 0.9 or higher and plotted using Cytoscape with a spring-embedded layout. Each prey is coloured to indicate its primary localization (rank in NMF terminology) as indicated in the legend. An interactive version of the map can be viewed at humancellmap.org/explore/maps and toggling from t-SNE to correlation on the bottom menu. b, Pfam regions or motifs enriched in the indicated NMF ranks. The heat map value represents the log2-transformed fold change between the genes localized to the rank and all preys in the dataset. Only compartments/ranks with a significant fold change for at least one motif are displayed on the heat map.

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