Extended Data Fig. 7: Sequence conservation among SARS-related betacoronaviruses, MERS-CoV and endemic human coronaviruses.
From: Neutralizing antibody vaccine for pandemic and pre-emergent coronaviruses
a, b Sequence similarity of RBD (a) and spike protein (b) for representative betacoronaviruses. Heat maps displaying pairwise amino acid sequence similarity for 57 representative betacoronaviruses. Dark blue shading indicates high sequence similarity. c, List of viruses used for alignments in a, b and Fig. 3f. d, Phylogenetic tree of representative betacoronavirus RBD sequences. Group 2b betacoronaviruses of interest are shown highlighted in red. Branch length units are substitutions per site.
