Extended Data Fig. 3: Reverse-phase HPLC analysis of erythroid cells derived from in vitro differentiation of edited SCD CD34+ HSPCs.
From: Base editing of haematopoietic stem cells rescues sickle cell disease in mice
Reverse-phase HPLC chromatograms of erythroid cell lysates at culture day 18, with β-like globins and their associated fractions marked near the associated peak. Data from the most efficiently edited donor cells are shown. Red arrows indicate the start and end of globin chain peaks.
