Extended Data Fig. 8: Extended analysis of genes distinguishing between branches in URD tree.
From: Molecular logic of cellular diversification in the mouse cerebral cortex
Related to Fig. 3. a, Feature importance (0.5 power transformed, dot size) and average expression of genes predicted to be involved in cell-type divergence (row-scaled, colour). Top 10 genes per branch, ranked by their Friedman MSE score (importance) for distinguishing between cells in one branch versus cells in sibling and parent branch. The colour bar at the top indicates branch-points marked on the tree to the left. Genes in red correspond to TFs. Expression in parent branch not shown. b, Gene Ontology analysis showing molecular function enrichment among genes involved in branch-points as determined in a. c, Simplified URD branching trees on which average gene expression within a segment and a pseudotime bin is overlaid on the tree structure, showing restricted expression patterns of genes identified in a.
