Extended Data Fig. 4: Cell-type-specific changes in gene expression and intercellular signalling in the brain of individuals with COVID-19.
From: Dysregulation of brain and choroid plexus cell types in severe COVID-19
a, Heat map displaying the number of significant biological pathways among the set of DEGs in each cell type (FDR < 0.05, Benjamini–Hochberg adjustment, hypergeometric test). Number of significant pathways is indicated in graded black (low) to yellow (high). b, Example upregulation of inflammatory and dysregulation of homeostatic genes in COVID-19 astrocytes. c, Comparison of the number of nuclei isolated per cell type and the number of predicted DEGs. Two-sided P-value indicates the significance of the correlation (Pearson, not significant).
