Extended Data Fig. 4: Fungal burden and GO term enrichment analysis of RNA-seq comparison of C. albicans in monocolonized wild-type and Rag1−/− mice.
From: Adaptive immunity induces mutualism between commensal eukaryotes
a, Fungal burden in wild-type and Rag1−/− mice monocolonized with C. albicans four weeks after inoculation. Mean values ± s.d. b, c, Biological process (b) or molecular function (c) GO term enrichment in genes with q ≤ 0.05 and log2-transformed fold change ≥ 1 or ≤ −1. d, Volcano plot of the ratio of C. albicans transcripts in wild-type and Rag1−/− mice with active transmembrane transporter activity genes labelled in red (n = 5 wild type and 4 Rag1−/− mice for a–d; one experiment). e, C. albicans morphology in colon contents from monocolonized wild-type or Rag1−/− mice four weeks after colonization. Mean values ± s.d. (n = 3 mice per group; one experiment). f, IgA binding to C. albicans in the faeces of antibiotic-treated wild-type and μMT−/− mice four weeks after inoculation. Mean values ± s.d. (n = 5 mice per group; one experiment). P values calculated using two-way ANOVA with Sidak’s multiple comparisons test (a, f) or two-sided unpaired t-test (e).
