Extended Data Fig. 7: Autoantibodies and inflammatory markers in participants who received at least one dose of the BNT162b2 vaccine and relationship to SARS-CoV-2 spike-specific IgG and SARS-CoV-2 PV neutralization.
From: Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
n = 101. a, Heatmap of log2-transformed fluorescence intensity of 19 autoantibodies; red, positive; blue, negative. b, Age (mean ± s.d.) in years by anti-MPO antibody-positive (red) or -negative (blue) status. c, IgG subclass responses to spike after first dose of BNT162b2 vaccine in individuals with or without anti-MPO antibodies (n = 100). d, GMT ± s.d of sera from individuals after their first dose of vaccine against wild-type and B.1.1.7 spike mutant SARS-CoV-2 PVs by anti-MPO antibody status. e, Nonparametric rank correlation (Kendall’s tau-b) of wild-type (WT) PV neutralization, variant (B.1.17) PV neutralization and age (<80 or ≥80 years) against each of 53 cytokines or chemokines. Heatmaps illustrate Tau-b statistic (left) and significance (right, –log10FDR).
