Extended Data Fig. 3: Binding IgG and IgA spike antibody responses following BNT162b2 vaccination.
From: Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
a, Correlations between serum binding IgG subclass 1–4 antibody responses following vaccination with first dose of BNT162b2 and age in years (n = 133). b, Correlations between serum binding IgG subclass 1–4 antibody responses following vaccination with first dose of BNT162b2 and serum neutralization using a PV system (n = 133). c, IgA responses to spike, nucleocapsid and RBD after first dose (light green, n = 133) and second dose (dark green, n = 21) compared to individuals with prior infection (red, n = 18) and negative controls (grey, n = 18) at serum dilution of 1 in 100. d, Correlations between serum binding IgA spike antibody responses following vaccination with first dose of BNT162b2 and serum neutralization using a PV system (n = 133). Bonferroni adjustment was made for multiple comparisons. Spike proteins tested are Wuhan-1 with D614G (WT). Linear regression lines plotted bounded by 95% CI.
