Extended Data Fig. 5: B cell repertoire following vaccination with first dose of BNT162b2.

a, Isotype usage according to unique VDJ sequence in <80-year-old (n = 22) and ≥80-year-old groups (n = 28). Differences between groups were calculated using Mann–Whitney U-test. b, V gene usage as a proportion, by neutralization of spike PV. Neutralization cut-off for 50% neutralization was set at 20. Differences between groups were calculated using Mann–Whitney U-test. c, Diversity indices comparing the two age groups. The inverse is depicted for Simpson’s index and the Shannon–Weiner index is normalized. Differences between groups were calculated using a t-test. For boxplots: centre line, median; box, 25th–75th percentile; whiskers, 1.5× IQR.